Afatinib (BIBW 2992)

作者：Prim N; Fore M; Mennecier B^*

来源：Revue de Pneumologie Clinique, 2014, 70(5): 279-285.

DOI：10.1016/j.pneumo.2014.03.002

• Afatinib
• BIBW 2992
• Lung cancer
• Tyrosine kinase
• inhibitor
• EGFR

Afatinib (BIBW 2992) is an irreversible multi-target HER receptor tyrosine kinase inhibitor developed in patients with advanced solid tumours. Several phase I studies were conducted in patients with non-small cell lung cancer (NSCLC), as a single agent or in combination. In further phase II or III studies, patients were selected based on the duration of response to first generation EGFR-TKI in previous line (supposed to have greater chance to have an activating EGFR mutation) or based directly on the EGFR activating mutation status. Here, we report and comment the main results of these studies in lung cancer patients. This drug has been approved by the Food and Drug Administration in June 2013 for the first-line treatment of patients with metastatic NSCLC whose tumours have EGFR mutation. In Europe, it has been approved in September 2013 in the same indication.

• 出版日期2014-10