Apoptotic Signaling Pathways in Glioblastoma and Therapeutic Implications

作者：Anahi Valdes Rives Silvia; Casique Aguirre Diana; German Castelan Liliana; Velasco Velazquez Marco A^*; Gonzalez Arenas Aliesha^*

来源：Biomed Research International, 2017, 2017: 7403747.

DOI：10.1155/2017/7403747

Glioblastoma multiforme (GBM) is the most hostile type of brain cancer. Its aggressiveness is due to increased invasion, migration, proliferation, angiogenesis, and a decreased apoptosis. In this review, we discuss the role of key regulators of apoptosis in GBM and glioblastoma stem cells. Given their importance in the etiology and pathogenesis of GBM, these signaling molecules may represent potential therapeutic targets.

• 出版日期2017