Forty-five years of cell-cycle genetics

作者:Reid Brian J; Culotti Joseph G; Nash Robert S; Pringle John R*
来源:Molecular Biology of the Cell, 2015, 26(24): 4307-4312.
DOI:10.1091/mbc.E14-10-1484

摘要

In the early 1970s, studies in Leland Hartwell's laboratory at the University of Washington launched the genetic analysis of the eukaryotic cell cycle and set the path that has led to our modern understanding of this centrally important process. This 45th-anniversary Retrospective reviews the steps by which the project took shape, the atmosphere in which this happened, and the possible morals for modern times. It also provides an up-to-date look at the 35 original CDC genes and their human homologues.

  • 出版日期2015-12-1