Multiple sclerosis and vitamin D during pregnancy and lactation

作者：Jalkanen A^*; Kauko T; Turpeinen U; Hamalainen E; Airas L

来源：Acta Neurologica Scandinavica, 2015, 131(1): 64-67.

DOI：10.1111/ane.12306

• multiple sclerosis
• lactation
• post-partum
• pregnancy
• vitamin D

BackgroundBoth pregnancy and high vitamin D concentration seem to generate a protective environment against multiple sclerosis (MS) relapses. Longitudinal case-control analysis of vitamin D concentrations during pregnancy and lactation of MS mothers is lacking.
Aims of the studyTo examine serum 25-hydroxyvitamin-D-3 levels of MS patients during and after pregnancy and compare these to the levels measured in healthy controls.
MethodsFifteen relapsing-remitting MS mothers underwent repeated testing for 25-hydroxyvitamin-D-3 at 10-12, 26-28 and 35-37 gestational weeks and 1, 3 and 6months post-partum. An identical series of samples was collected from six control mothers.
ResultsThe prevalence of vitamin D deficiency (<50nmol/l) during pregnancy was high (73%) among MS patients. Vitamin D levels were significantly higher during pregnancy when compared to early post-partum values among MS patients. At the end of the follow-up period, the vitamin D levels returned to levels observed in early pregnancy. In healthy controls, the alterations during and after pregnancy were similar in nature, but the vitamin D concentrations were higher at all time points when compared to MS patients (P=0.037).
ConclusionsVitamin D deficiency during the pregnancy and lactation seems to be common in mothers with MS and needs to be treated adequately.

• 出版日期2015-1