Differential expression of STAT1 and IFN- in primary and invasive or metastatic wilms tumors

作者：Liu, Wei; Zhang, Lijuan; Wu, Rongde^*

来源：Journal of Surgical Oncology, 2013, 108(3): 152-156.

DOI：10.1002/jso.23364

• Wilms tumor
• S
• IFN-
• metastasis
• invasion

Background and Objectives: IFN/STAT1 signaling has been found to be not only associated with an aggressive tumor phenotype but also activated and functional during metanephric development. This study was undertaken to evaluate STAT1 and IFN-gamma expression and its relation to histopathological features of primary and invasive/metastatic Wilms tumors.
Methods: Immunohistochemistry was used to determine the expression and cellular distribution of STAT1 and IFN-gamma in 18 pairs of primary and corresponding invasive/metastatic Wilms tumors and 40 primary tumors without invasion or metastasis.
Results: Positive rate of STAT1/IFN-gamma expression was 66.7%/61.1% and 72.2%/77.8% in 18 pairs of primary and associated invasive/metastatic Wilms tumor tissues, while 35.0%/27.5% in 40 primary tumors without invasion or metastasis. The expression of STAT1 and IFN-gamma was significantly associated with invasion/metastasis (P 0.025; P 0.015). There was a positive correlation between STAT1 and IFN-gamma expression in all Wilms tumor tissues (chi(2) = 23.408, P = 0.05, r = 0.555). The expression of STAT1 and IFN-gamma between primary and matched invasive/metastatic tissues was concordance, respectively (P = 0.710 and P = 0.375).
Conclusions: These results suggest that IFN-gamma/STAT1 signaling might have clinical potential as a promising predictor to identify individuals with poor prognostic potential and as a possible novel target molecule of therapy for Wilms tumor.

• 出版日期2013-9
• 单位山东大学