Mechanical Induction of BMP-7 in Osteocyte Blocks Glucocorticoid-Induced Apoptosis Through PI3K/AKT/GSK3 beta Pathway

作者：Wang Zhaohong; Guo Jun^*

来源：Cell Biochemistry and Biophysics, 2013, 67(2): 567-574.

DOI：10.1007/s12013-013-9543-6

• BMP-7
• Osteocyte
• Apoptosis
• GSK3 beta

Mechanical loading is known to promote osteocyte survival, whereas glucocorticoid treatment results in osteocyte apoptosis. Here, we report that BMP-7, which was secreted by osteocyte in response to mechanical loading, exerts anti-apoptotic effect against dexamethasone-induced apoptosis of osteocytes. We further show that the anti-apoptotic effect of BMP-7 is mainly mediated through receptor BMPR2 and is associated with the activation of PI3K/AKT/GSK3 beta pathway.

• 出版日期2013-11
• 单位重庆医科大学