Apoptosis induction by Maackia amurensis agglutinin in childhood acute lymphoblastic leukemic cells

作者：Kapoor Sarika; Marwaha Ram; Majumdar Siddhartha; Ghosh Sujata^*

来源：Leukemia Research, 2008, 32(4): 559-567.

DOI：10.1016/j.leukres.2007.08.007

• acute lymphoblastic leukemia
• Maackia amurensis agglutinin
• apoptosis

Malignant transformation is known to be associated with changes in cell surface carbohydrate-architecture, which can be detected by lectins. In the present study, Maackia amurensis agglutinin (MAA), specific for NeuNAc alpha(2 -> 3)Gal/GalNAc showed strong binding with lymphoblasts of children having acute lymphoblastic leukemia (ALL) as compared to cells from children with non-hematological disorders ("Controls"). MAA recognized a 66 kDa sialoglycoprotein present in membrane fraction of ALL cells. Moreover, MAA induced apoptosis in ALL cells was found to be reduced significantly in presence of GM2/IgG(MAA). Thus, MAA has a potential to be used as diagnostic and therapeutic agent in case of childhood-ALL.

• 出版日期2008-4
• 单位河北医科大学