摘要
The aim of this study was to investigate the expression of Nrf2, sulfiredoxin and DJ1 in pancreatic cancer. The expression of Nrf2, sulfiredoxin and DJ1 was studied immunohistochemically in a large set of pancreatic adenocarcinomas consisting of 103 cases. %26lt;br%26gt;Eighty six percent of the cases showed cytoplasmic Nrf2 and 24% nuclear Nrf2 positivity. Sulfiredoxin positivity was observed in 54% and DJ1 positivity in all cases. Nuclear Nrf2 positivity had an association with sulfiredoxin (p = 0.019) and was associated with a poor survival (p = 0.010). Stage IV tumors tended to have a more nuclear Nrf2 expression (p = 0.080). DJ1 expression was more often found in well-differentiated tumors (p = 0.012), and DJ1 expression was associated with better survival (p = 0.020). %26lt;br%26gt;According to the results, nuclear Nrf2 expression predicts a worse survival in pancreatic adenocarcinoma, which is in keeping with its protection of cells against oxidative or xenobiotic stress. In accordance with Nrf2%26apos;s regulation of the synthesis of sulfiredoxin, there was an association between them (p = 0.019). DJ1 had no association with Nrf2, and its expression predicted a better survival of patients.
- 出版日期2014