Novel mononuclear Pt2+ and Pd2+ complexes containing (2,3-f)pyrazino(1,10)phenanthroline-2,3-dicarboxylic acid as a multi-donor ligand. Synthesis, structure, interaction with DNA, in vitro cytotoxicity, and apoptosis

作者：Sun, Ya-guang; Sun, Yi-ning; You, Li-xin; Liu, Yi-nan; Ding, Fu; Ren, Bao-yi; Xiong, Gang; Dragutan, Valerian; Dragutan, Ileana^*

来源：Journal of Inorganic Biochemistry, 2016, 164: 129-140.

DOI：10.1016/j.jinorgbio.2016.09.008

• Pt2+ and Pd2+ coordination complexes
• Phenanthroline ligands
• Cytotoxicity
• Apoptosis
• DFT calculations

New cytotoxic, mononuclear Pt and Pd coordination complexes featuring the planar, multi-donor ligand (2,3-f)pyrazino(1,10)phenanthroline-2,3-dicarboxylic acid (H(2)PPDA) have been synthesized under hydrothermal conditions (in water, at high temperature and pressure) and fully characterized. The complexes were proven to be isostructural by applying the single-crystal X-ray diffraction technique. IJV-Vis and fluorescence spectroscopy investigations on their interaction with fish sperm DNA revealed a considerable binding capacity while gel electrophoresis provided evidence in favor of cleavage of pBR322 plasmid DNA. The newly synthesized complexes manifested significant in vitro cytotoxic activity against two different human cancer cell lines, the KB and JEKO cells, with cell death mainly caused by apoptosis.

• 出版日期2016-11
• 单位南开大学; 沈阳化工大学; 沈阳工业大学