A Knockout Combo: Eradicating AML Stem Cells with TKI plus SIRT1 Inhibition

作者：Zeisig Bernd B; So Chi Wai Eric^*

来源：Cell Stem Cell, 2014, 15(4): 395-397.

DOI：10.1016/j.stem.2014.09.006

SIRT1 inhibition facilitates elimination of CML stem cells by Imatinib, in part via p53 activation. In this issue of Cell Stem Cell, Li et al. (2014) demonstrate a similar role for SIRT1 inhibition in eradicating FLT3-ITD AML stem cells, potentially through a positive feedback loop with c-MYC, highlighting SIRT1 as a potential target in combination cancer therapy.

• 出版日期2014-10-2