A cationic gadolinium contrast agent for magnetic resonance imaging of cartilage

作者:Freedman Jonathan D; Lusic Hrvoje; Wiewiorski Martin; Farley Michelle; Snyder Brian D; Grinstaff Mark W*
来源:Chemical Communications, 2015, 51(56): 11166-11169.
DOI:10.1039/c5cc03354c

摘要

A new cationic gadolinium contrast agent is reported for delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC). The agent partitions into the glycosaminoglycan rich matrix of articular cartilage, based on Donnan equilibrium theory, and its use enables imaging of the human cadaveric metacarpal phalangeal joint.