Protein-ligand binding investigated by a single nanoparticle TERS approach

作者:Carrier Stacey L; Kownacki Corey M; Schultz Zachary D*
来源:Chemical communications, 2011, 47(7): 2065-2067.
DOI:10.1039/c0cc05059h

摘要

We report TERS imaging of individual 50 nm, biotin-labeled gold nanoparticles bound to a streptavidin-derivatized glass slide. Individual gold nanoparticles detected by a nanoparticle TERS tip generate Raman enhancements in both the biotin and streptavidin signals. These results indicate that nanoparticles are capable of investigating nanoscale spatial and chemical environments with non-resonant Raman enhancements.

  • 出版日期2011