Aortic stiffness and blood pressure variability in young people: a multimodality investigation of central and peripheral vasculature

作者：Boardman Henry; Lewandowski Adam J; Lazdam Merzaka; Kenworthy Yvonne; Whitworth Polly; Zwager Charlotte L; Francis Jane M; Aye Christina Y L; Williamson Wilby; Neubauer Stefan; Leeson Paul

来源：Journal of Hypertension, 2017, 35(3): 513-522.

DOI：10.1097/HJH.0000000000001192

• aortic stiffness
• blood pressure variability
• pulse wave velocity
• young adults

Introduction: Increased blood pressure (BP) variability is a cardiovascular risk marker for young individuals and may relate to the ability of their aorta to buffer cardiac output. We used a multimodality approach to determine relations between central and peripheral arterial stiffness and BP variability.
Methods: We studied 152 adults (mean age of 31 years) who had BP variability measures based on SD of awake ambulatory BPs, 24-h weighted SD and average real variability (ARV). Global and regional aortic distensibility was measured by cardiovascular magnetic resonance, arterial stiffness by cardio-ankle vascular index (CAVI) and pulse wave velocity (PWV) by SphygmoCor (carotid-femoral) and Vicorder (brachial-femoral).
Results: In young people, free from overt cardiovascular disease, all indices of SBP and DBP variability correlated with aortic distensibility (global aortic distensibility versus awake SBP SD: r = -0.39, P<0.001; SBP ARV: r = -0.34, P<0.001; weighted 24-h SBP SD: r = -0.42, P<0.001). CAVI, which closely associated with aortic distensibility, also related to DBP variability, as well as awake SBP SD (r = 0.19, P<0.05) and weighted 24-h SBP SD (r = 0.24, P<0.01), with a trend for SBP ARV (r = 0.17, P=0.06). In contrast, associations with PWV were only between carotid-femoral PWV and weighted SD of SBP (r = 0.20, P = 0.03) as well as weighted and ARV of DBP.
Conclusion: Greater BP variability in young people relates to increases in central aortic stiffness, strategies to measure and protect aortic function from a young age may be important to reduce cardiovascular risk.

• 出版日期2017-3