Adipocyte-fatty acid binding protein and non-alcoholic fatty liver disease in the elderly

作者：Masetti Marco^*; Bianchi Giampaolo; Gianotti Giordano; Giovagnoli Marco; Vizioli Luca; Zorzi Veronica; Rossi Valentina; Forti Paola; Zoli Marco

来源：Aging Clinical and Experimental Research, 2014, 26(3): 241-247.

DOI：10.1007/s40520-013-0156-0

• Metabolic syndrome
• Metaflammation
• Non-alcoholic fatty liver disease

Background Adipocyte-fatty acid binding protein (A-FABP) is an intracellular lipid transporter that mediates metabolically triggered inflammation, and it is associated with insulin resistance, atherogenic dyslipidemia, and cardiovascular risk.
Aims The aim of this study was to evaluate A-FABP behavior in elderly people, and especially its association with liver steatosis at abdominal ultrasound.
Method Cross-sectional study of two cohort of individuals with and without steatosis, with assessment of several clinical and laboratory variables. Prospective evaluation of liver steatosis remodeling after six years of follow-up. One hundred and fifty-six subjects aged over 65 years were enrolled.
Results Serum A-FABP positively correlated with body fat percentage, total cholesterol, serum triglycerides and erythrocyte sedimentation rate. Unlike expected, high A-FABP levels were associated with absence of liver steatosis, while there was no evidence of association with steatosis grade changes after 6 years of follow-up.
Conclusion Among individuals aging more than 65 years included in the study, A-FABP was inversely associated with liver steatosis. It can be argued, that still uncovered mechanisms modify A-FABP behavior in elderly people, especially its association with multifactorial diseases.

• 出版日期2014-6