A Direct Access to N-Arylation of Guanidines by Ligand-free, Copper Catalysis at Room Temperature

作者：Nematpour Manijeh^*; Abedi Elham; Abedi Elahe

来源：Letters in Organic Chemistry, 2018, 15(8): 678-681.

DOI：10.2174/1570178615666171222162430

• N-Arylation
• ullmann coupling
• guanidine
• copper-catalyzed
• aryl halides
• organic

The copper (I)-catalyzed cross-coupling reactions between aryl halides and guanidines to produce N-aryl guanidines have been developed. Mild reaction conditions, good yields, ligand-free, easy work-up, no column chromatography, and ease of handling at room temperature are the main aspects of the method.

• 出版日期2018