Understanding the influence of MgO and SrO binary doping on the mechanical and biological properties of beta-TCP ceramics

作者：Banerjee Shashwat S; Tarafder Solaiman; Davies Neal M; Bandyopadhyay Amit; Bose Susmita^*

来源：Acta Biomaterialia, 2010, 6(10): 4167-4174.

DOI：10.1016/j.actbio.2010.05.012

• beta-Tricalcium phosphate
• MgO doping
• SrO doping
• In vivo behavior
• Biocompatibility

The objective of this study was to evaluate the influence of MgO and SrO doping on the mechanical and biological properties of beta-tricalcium phosphate (beta-TCP). beta-TCP was doped with two different binary compositions, 0.25 and 1.0 wt % SrO along with 1.0 wt % MgO MgO and SrO doping increased the beta phase stability at a sintering temperature of 1250 degrees C and marginally decreased the compressive strength of beta-TCP An in vitro cell-material interaction study, using human fetal osteoblast cells (hFOB), indicated that doped beta-TCP was non-toxic, and MgO/SrO dopants improved cell attachment and growth. beta-TCP Implants doped with 1.0 wt.% MgO and 1.0 wt.% SrO showed good in vivo biocompatibility when tested in male Sprague-Dawley rats for 16 weeks Histomorphology analysis indicated that MgO/SrO-doped beta-TCP promoted more osteogenesis than pure beta-TCP In vivo osteocalcin and type I collagen assay also revealed faster bone formation in rats with doped beta-TCP implant compared to rats with pure beta-TCP implant Low Ca(2+) concentration in the urine of rats with doped beta-TCP implant confirmed slower degradation of MgO/SrO-doped beta-TCP than pure beta-TCP.

• 出版日期2010-10