Nuclear Y-box-binding protein-1 is a poor prognostic marker and related to epidermal growth factor receptor in uterine cervical cancer

作者：Nishio Shin^*; Ushijima Kimio; Yamaguchi Tomohiko; Sasajima Yuko; Tsuda Hitoshi; Kasamatsu Takahiro; Kage Masayoshi; Ono Mayumi; Kuwano Michihiko; Kamura Toshiharu

来源：Gynecologic Oncology, 2014, 132(3): 703-708.

DOI：10.1016/j.ygyno.2014.01.045

• YB-1
• EGFR
• Cervical cancer

Objective. Y-box binding protein-1 (YB-1) is a member of the cold shock protein family and functions in transcription and translation. Many studies indicate that YB-1 is strongly expressed in tumor cells and is considered a marker of tumor aggressiveness and clinical prognosis. Overexpression of epidermal growth factor receptor (EGFR) has been associated with poor outcomes in cervical cancer. Clinical trials of EGFR family-base therapy are currently being initiated in cervical cancer. Nuclear YB-1 expression correlates with EGFR expression in various types of cancer. However, the clinical significance of nuclear YB-1 expression in different settings, the correlation with EGFR, and the prognostic implications of YB-1 expression in cervical cancer remain elusive. %26lt;br%26gt;Patients and methods. Nuclear YB-1 expression was immunohistochemically analyzed in tissue specimens obtained from 204 patients with, cervical cancer who underwent surgery. Associations of nuclear YB-1 expression with clinicopathological factors such as survival, EGFR expression, and human epidermal growth factor receptor 2 (HER2) expression were investigated. %26lt;br%26gt;Results. Nuclear YB-1 expression was found in 41(20.2%) of 204 cases of cervical cancer and correlated with disease stage, tumor diameter, stromal invasion, and lymph-node metastasis. Nuclear YB-1 expression also correlated with EGFR expression (P = 0.0114) as well as HER2 expression (P = 0.0053). Kaplan-Meier survival analysis showed that nuclear YB-1 expression was significantly associated with poor progression-free survival (P = 0.0033) and overall survival (P = 0.0003), respectively. %26lt;br%26gt;Conclusion. Nuclear YB-1 expression is a prognostic marker and correlates with EGFR expression in cervical cancer.

• 出版日期2014-3