Dietary omega 3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut

作者：Kunisawa Jun^*; Arita Makoto; Hayasaka Takahiro; Harada Takashi; Iwamoto Ryo; Nagasawa Risa; Shikata Shiori; Nagatake Takahiro; Suzuki Hidehiko; Hashimoto Eri; Kurashima Yosuke; Suzuki Yuji; Arai Hiroyuki; Setou Mitsutoshi; Kiyono Hiroshi

来源：Scientific Reports, 2015, 5(1): 9750.

DOI：10.1038/srep09750

omega 3 polyunsaturated fatty acids (PUFAs) have anti-allergic and anti-inflammatory properties, but the immune-metabolic progression from dietary oil remains to be investigated. Here we identified 17,18-epoxyeicostetraenoic acid (17,18-EpETE) as an anti-allergic metabolite generated in the gut from dietary omega 3 alpha-linolenic acid (ALA). Biochemical and imaging mass spectrometry analyses revealed increased ALA and its metabolites, especially eicosapentaenoic acid (EPA), in the intestines of mice receiving ALA-rich linseed oil (Lin-mice). In murine food allergy model, the decreased incidence of allergic diarrhea in Lin-mice was due to impairment of mast cell degranulation without affecting allergen-specific serum IgE. Liquid chromatography-tandem mass spectrometry-based mediator lipidomics identified 17,18-EpETE as a major omega 3 EPA-derived metabolite generated from dietary ALA in the gut, and 17,18-EpETE exhibits anti-allergic function when administered in vivo. These findings suggest that metabolizing dietary omega 3 PUFAs generates 17,18-EpETE, which is an endogenous anti-allergic metabolite and potentially is a therapeutic target to control intestinal allergies.

• 出版日期2015-6-11
• 单位RIKEN; 河北医科大学