An effective peptide cargo carrier for the delivery of cisplatin in ovarian cancer cells

作者：Lai, Yanhua; Zhao, Ping; Zhang, Zhan; Li, Bai^*; Wu, Junchen^*

来源：Dyes and Pigments, 2017, 143: 342-347.

DOI：10.1016/j.dyepig.2017.04.025

• Peptide cargo carrier
• Targeted delivery
• Cisplatin
• Ovarian cancer
• Disassembly

The self-assembled peptide cargo carrier with the ability of probe offered an effective strategy to deliver and track the anticancer drug, cisplatin (DDP) in ovarian cancer cells. This simple peptide system containing a pyrene fluorogen and arginine-glycine-aspartic acid (RGD) sequence could be utilized to release DDP in situ by the specific recognition between an RGD motif and alpha(v)beta(3) integrin that was over-expressed on ovarian cancer cells. Importantly, we found that the disassembly-triggered peptide nanofibers, PA1, could effectively combine with DDP and release DDP in the cytoplasm with the pyrene fluorescence restoring. Moreover, the peptide cargo carrier efficiently penetrated tumour cells for enhancing therapeutic efficacy. Our system could open the door for the delivery of anticancer drug in cancer-related therapy.

• 出版日期2017-8
• 单位华东理工大学