Adverse facial edema associated with off-label use of recombinant human bone morphogenetic protein-2 in cranial reconstruction for craniosynostosis - Case report

作者：Shah M Mohsin^*; Smyth Matthew D; Woo Albert S

来源：Journal of Neurosurgery-Pediatrics, 2008, 1(3): 255-257.

DOI：10.3171/PED/2008/1/3/255

• bone morphogenetic protein
• craniofacial surgery
• craniosynostosis repair
• metopic synostosis

The authors present a case of scalp and facial edema following craniofacial reconstruction for metopic craniosynostosis in which recombinant human bone morphogenetic protein-2 (rhBMP-2) was used to treat cranial defects related to the frontoorbital reconstruction. The extent of swelling, the onset, and duration were unusual for such cases and Suggested a possible role of rhBMP-2 in inducing a local inflammatory response. The edema rapidly resolved after the patient underwent surgery to remove the rhBMP-2 implants.

• 出版日期2008-3