Apicomplexa in mammalian cells: Trafficking to the parasitophorous vacuole

作者：Ce**ron Delauw Marie France^*; Gendrin Claire; Travier Laetitia; Ruffiot Pauline; Mercier Corinne

来源：Traffic, 2008, 9(5): 657-664.

DOI：10.1111/j.1600-0854.2008.00728.x

• Apicomplexa
• dense granules
• membranous nanotubular network
• parasitophorous vacuole
• Plasmodium spp
• rhoptries
• Toxoplasma gondii
• tubovesicular network

Most Apicomplexa reside and multiply in the cytoplasm of their host cell, within a parasitophorous vacuole (PV) originating from both parasite and host cell components. Trafficking of parasite-encoded proteins destined to membrane compartments beyond the confine of the parasite plasma membrane is a process that offers a rich territory to explore novel mechanisms of protein-membrane interactions. Here, we focus on the PVs formed by the asexual stages of two pathogens of medical importance, Plasmodium and Toxoplasma. We compare the PVs of both parasites, with a particular emphasis on their evolutionary divergent compartmentalization within the host cell. We also discuss the existence of peculiar export mechanisms and/or sorting determinants that are potentially involved in the post-secretory targeting of parasite proteins to the PV subcompartments.

• 出版日期2008-5