Preparation and Characterization of Deoxycholic Acid-Grafted Hyaluronic Acid as a Durg Carrier

作者：Choi Changyong; Park Jun Kyu; Kim Won Suk; Jang Mi Kyeong^*; Nah Jae Woon

来源：Polymer-Korea, 2011, 35(2): 119-123.

DOI：10.7317/pk.2011.35.2.119

• hyaluronic acid
• bile acid
• deoxycholic acid
• drug carrier
• nanoparticle

To develop hyaluronic acid (HA)-based anticancer agent carrier, hyaluronic acid was chemically modified with the hydrophobic group of deoxycholic acid (DA). The physicochemical properties of the deoxycholic acid-conjugated HA (HADA) were investigated by using (1)H NMR, FTIR, spectrophotometer and TEM. Paclitaxel (Tx)-loaded HADA nanoparticles were prepared by a dialysis method. The loading efficiency of drug and drug contents of Tx-loaded HADA nanoparticles (HADA-Tx) were measured by HPLC. The anticancer activity of HADA-Tx was investigated by its cytotoxicity against KB cell in vitro. The HADA-Tx was shown to have the superior potential for the anticancer drug delivery.

• 出版日期2011-3