Clinical Relevance of Different Handgrip Strength Indexes and Mobility Limitation in the Elderly Adults

作者：Dong, Renwei; Wang, Xiuyang; Guo, Qi^*; Wang, Jiazhong; Zhang, Wen; Shen, Suxing; Han, Peipei; Ma, Yixuan; Kang, Li; Wang, Menglu; Fu, Liyuan; Jia, Liye; Wang, Liancheng; Niu, Kaijun

来源：Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 2016, 71(1): 96-102.

DOI：10.1093/gerona/glv168

• Aging
• Mobility limitation
• ROC analysis
• Relative handgrip strength indexes

More efficient clinical indexes are needed to identify older people most likely to present mobility impairments. The aim of the present study was to determine which handgrip strength (HS) indexes are clinically relevant to detect risk of mobility limitation in the elderly adults. In addition, we attempted to determine an optimal cutoff point for the most relevant index.
Data are from 469 men and 609 women aged 60 years and older recruited in the Hangu area of Tianjin, China. Participants scoring in the top 20% on the Timed Up and Go Test or in the slowest 20% for the 4-m walk test were defined as having mobility limitation.
The prevalence of mobility limitation was 27.6% in women and 24.5% in men. The area under the receiver-operating characteristic curve for HS/body fat mass was 0.723 (95% confidence interval [CI] = 0.658-0.788) in men and for HS/weight was 0.684 (95% CI = 0.628-0.739) in women. These values were indicated higher levels of mobility limitation compared with HS and other relative HS indexes. The cutoffs of the most relevant index in men and women that effectively identified individuals at risk of mobility limitation were 1.884 and 0.281, respectively.
HS/body fat mass and HS/weight appear to be the indices best associated with mobility limitation for men and women, respectively. Optimal cutoffs for clinically relevant index have the potential to identify elderly adults at risk of mobility limitation.

• 出版日期2016-1
• 单位泰达国际心血管病医院; 天津医科大学; 天津市天津医院