Novel Mechanism for Fluoroquinolone Resistance in Acinetobacter baumannii

作者：Saroj Sunil D; Clemmer Katy M; Bonomo Robert A; Rather Philip N^*

来源：Antimicrobial Agents and Chemotherapy, 2012, 56(9): 4955-4957.

DOI：10.1128/AAC.00739-12

An EZ::TN %26lt; R6K gamma ori/KAN-2 %26gt; Tnp transposon insertion in an open reading frame of unknown ncr) in Acinetobacter baumannii resulted in an 8-fold increase in ciprofloxacin resistance (Cip(r)). Transposon insertions in an ncr mutant that reduced Cip(r) back to wild type mapped to three genes encoding subunits of the RecCBD exonuclease. The ncr mutation increased transcription of the recCBD genes, and overexpression of the recCBD genes in a wild-type background resulted in a 4-fold increase in Cip(r).

• 出版日期2012-9