Antitumoral and anti-inflammatory activities of the red alga Sphaerococcus coronopifolius

作者：Salhi Ghizlane; Zbakh Hanaa^*; Moussa Hanaa; Hassoun Mustapha; Bochkov Valery; Ciudad Carlos J; Noe Veronique; Riadi Hassane

来源：European Journal of Integrative Medicine, 2018, 18: 66-74.

DOI：10.1016/j.eujim.2018.02.001

• Red alga
• Sphaerococcus coronopifolius
• Antitumoral
• Apoptosis
• Anti-inflammatory

Introduction: Algae are the source of a great variety of natural products exhibiting an array of biomedical properties associated with remedies of various kinds of diseases, including cancer and inflammatory bowel diseases. As a part of our research on bioactive products from algae, we aimed to study the isolation and pharmacological evaluation of marine natural products, we have analyzed specimens of the alga Sphaerococcus coronopifolius collected from the Moroccan Mediterranean Sea.
Methods: The antitumoral effect of S. coronopifolius extracts on human cervix, breast and pancreatic cancer cells was investigated via cell viability and apoptosis assays. The crude extracts were tested by IL-8 inhibition assays to evaluate their anti-inflammatory properties.
Results: S. coronopifolius extracts inhibited the growth of HeLa, SKBR-3 and MIA PaCa-2 cells in dose- and time-dependent manners. After treatment with the extracts, the apoptotic rate significantly increased in these cell lines. IL-8 secretion in LPS- and TNF-alpha-stimulated HUVEC-tert endothelial cells was found to be significantly inhibited by S. coronopifolius extracts.
Conclusion: The present study suggests that S. coronopifolius can significantly inhibit the proliferation of HeLa, SKBR-3 and MIA PaCa-2 cells, induces apoptosis and possesses interesting anti-inflammatory properties. Furthermore, its application as nutraceuticals and functional food could also be considered.

• 出版日期2018-2