Antiviral isoindolone derivatives from an endophytic fungus Emericella sp associated with Aegiceras corniculatum

作者：Zhang Guojian; Sun Shiwei; Zhu Tianjiao; Lin Zhenjian; Gu Jingyan; Li Dehai^*; Gu Qianqun

来源：Phytochemistry, 2011, 72(11-12): 1436-1442.

DOI：10.1016/j.phytochem.2011.04.014

• Emericella
• Endophytic fungus
• Aegiceras corniculatum
• Myrsinaceae
• Isoindolone derivatives
• Antiviral activity

Chemical investigation of the endophytic fungus Emericella sp. (HK-ZJ) isolated from the mangrove plant Aegiceras corniculatum led to isolation of six isoindolones derivatives termed as emerimidine A and B and emeriphenolicins A and D, and six previously reported compounds named aspernidine A and B, austin, austinol, dehydroaustin, and acetoxydehydroaustin, respectively. Their structures were elucidated on the basis of NMR spectroscopic evidence while the anti-influenza A viral (H(1)N(1)) activities of eight compounds were also evaluated using the cytopathic effect (CPE) inhibition assay.

• 出版日期2011-8
• 单位中国海洋大学