Stereocontrolled synthesis of all-syn 3,4-disubstituted L-prolines: studies of the reductive rearrangement of unactivated tertiary allylic alcohols

作者：Hanessian Stephen^*; Dorich Stephane; Kassem Salma; Menz Helge; Chattopadhyay Amit Kumar

来源：Tetrahedron, 2014, 70(2): 439-449.

DOI：10.1016/j.tet.2013.11.040

We describe a stereocontrolled method that converts tertiary allylic alcohols in pyrrolidine-2-carboxylic acid derivatives prepared from 3-(S)-hydroxy-L-proline to all-syn 3,4-disubstituted t-prolines. A study of various parameters to optimize the reductive rearrangement of tertiary allylic alcohols to tetrasubstituted olefins was conducted.

• 出版日期2014-1-14