MOTOR NEURON DISEASE Common genetic variants and the heritability of ALS

作者:Al Chalabi Ammar*; Visscher Peter M
来源:Nature Reviews Neurology, 2014, 10(10): 549-+.
DOI:10.1038/nrneurol.2014.166

摘要

Amyotrophic lateral sclerosis (ALS) shows complex inheritance. A new meta-analysis of three data sets has replicated previous estimates of the heritability attributable to common genetic variation, corroborated some previously identified disease-associated genetic loci, and suggested novel loci. Despite such efforts, our understanding of the genetic architecture of ALS remains limited.

  • 出版日期2014-10