ASSOCIATION OF POLYMORPHISM TAQI OF VITAMIN DE RECEPTOR WITH BONE MINERAL DENSITY IN YOUNG MEXICAN WOMEN

作者：Jimenez Salas Z^*; Hernandez Tobias E A; Ramirez Lopez T E; Campos Gongora E

来源：Nutricion Hospitalaria, 2012, 27(5): 1505-1510.

DOI：10.3305/nh.2012.27.5.5673

• Bone mineral density
• Polymorphism
• Taql
• VDR
• Osteoporosis

Introduction: Osteoporosis is a multifactorial disease characterized by a low bone mineral density (BMD). Osteoporosis and the occurrence of fractures in postmenopausal women have been associated to the Taql polymorphism in the vitamin D receptor (VDR) gene.
Objective: To analyze the association of the different genotypes of Taql polymorphism of the VDR gene with BMD in young Mexican women.
Methods: Dual X-ray absorptiometry was carried out in 150 women aged 19 to 29 years in order to determine their total bone mineral density (tBMD) and dual BMD of the femur (dfBMD). DNA was extracted from peripheral blood to determine the genotype of the Taql polymorphism in the VDR gene. The data obtained were analyzed by simple linear regression and ANOVA.
Results: Mean tBMD was 1.096 +/- 0.064 mean dfBMD was 0.960 +/- 0.107 g/cm(2). The frequency of the Taql polymorphisms was 57% (TI), 37% (It) and 6% (tt), the frequency of the alleles was 75% (T) and 25% (t). Ths statistical analysis showed a lack of association between BMD and the genotypes of Taql polymorphism in the VDR gene. Discussion and
conclusions: These results suggest that may exist factors other than the Taql polymorphism in the VDR gene contributing to BMD in young women from Northern Mexico. (Nutr Hosp. 2012;27:1505-1510) DOI:10.3305/nh.2012.27.5.5673

• 出版日期2012-10