科研之友
微信
新浪微博
Facebook
分享链接
摘要
Allylating agents were explored for the asymmetric synthesis of alpha-allyl-alpha-aryl alpha-amino acids by tandem N-alkylation/pi-allylation. Cross-metathesis of the tandem product was developed to provide allylic diversity not afforded in the parent reaction; the synthesis of homotyrosine and homoglutamate analogues was completed. Cyclic alpha-amino acid derivatives could be accessed by ring-closing metathesis presenting a viable strategy to higher ring homologue of enantioenriched alpha-substituted proline. The eight-membered proline analogue was successfully converted to the pyrrolizidine natural product backbone.
- 出版日期2014-6-6
