The changes in the indices of oxidative stress and the levels of nitric oxide and glucose in patients with craniocerebral trauma of moderate severity

作者：Klychnikova E V^*; Tazina E V; Kordonskii A Yu; Trifonov I S; Godkov M A; Krylov V V

来源：Neurochemical Journal, 2014, 8(2): 134-139.

DOI：10.1134/S1819712414020068

• craniocerebral trauma
• oxidative stress
• antioxidant system
• nitric oxide
• glucose

The pathophysiological mechanisms of brain lesions after craniocerebral trauma (CCT) are associated with the effects of primary and secondary damaging factors. Here, we studied the changes in the indices of oxidative stress, including the content of malondialdehyde (MDA), the total antioxidant activity (TAA), the MDA/TAA coefficient, albumin, and the levels of the markers of secondary damage, such as nitric oxide (NO (x) ) and glucose in the blood serum of patients with CCT of moderate severity. A total of 29 patients with CCT were examined on days 1, 3, and 5 of their stay in a hospital. On day 5 of the posttraumatic period, we observed the exhaustion of the antioxidant system expressed in the increased MDA/TAA coefficient and decreased TAA in patients with CCT of moderate severity. The NO (x) level was decreased on day 1 and on days 3 and 5 it was similar to the norm. The glucose level was normal during the entire observation period. A significant positive correlation between the MDA/TAA index and traumatic subarachnoid hemorrhage was revealed on day 5, which reflected the relationship between oxidative stress and the lesion volume. This should be taken into account for the selection of a therapeutic approach.

• 出版日期2014-4