High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8(+) and CD4(+) T cells during acute HCV infection, irrespective of clinical outcome

作者：Kasprowicz Victoria; Wiesch Julian Schulze zur; Kuntzen Thomas; Nolan Brian E; Longworth Steven; Berical Andrew; Blum Jenna; McMahon Cory; Reyor Laura L; Elias Nahel; Kwok William W; McGovern Barbara G; Freeman Gordon; Chung Raymond T; Klenerman Paul; Lewis Ximenez Lia; Walker Bruce D; Allen Todd M; Kim Arthur Y; Lauer Georg M^*

来源：Journal of Virology, 2008, 82(6): 3154-3160.

DOI：10.1128/JVI.02474-07

We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8(+) and CD4(+) T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high early in acute infection irrespective of clinical outcome, and most cells continued to express PD-1 in resolved and chronic stages of infection; intrahepatic expression levels were especially high. Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection.

• 出版日期2008-3