Activity of ibrutinib in mantle cell lymphoma patients with central nervous system relapse

作者：Bernard Sophie; Goldwirt Lauriane; Amorim Sandy; Brice Pauline; Briere Josette; de Kerviler Eric; Mourah Samia; Sauvageon Helene; Thieblemont Catherine

来源：Blood, 2015, 126(14): 1695-1698.

DOI：10.1182/blood-2015-05-647834

<jats:title>Key Points</jats:title>
<jats:p>Ibrutinib induces a rapid, dramatic, and sustained response in MCL patient with symptomatic CNS relapse. Ibrutinib penetration through the blood-brain barrier was confirmed using plasma and cerebrospinal fluid pharmacokinetic analyses.</jats:p>

• 出版日期2015-10-1
• 单位常州工学院