Acute autonomic effects of vitamins and fats in male smokers

作者：Wright C I^*; Ruediger H; Kroner C I; Janssen B J A; Draijer R

来源：European Journal of Clinical Nutrition, 2009, 63(2): 246-252.

DOI：10.1038/sj.ejcn.1602912

• baroreflex sensitivity
• spectral analysis
• blood-pressure variability
• heart-rate variability

Background/Objectives: Vitamins can help improve cardiovascular control. In contrast, smoking works in the opposite fashion, reducing the baroreflex control of heart rate (HR) possibly via oxidative stress. High-fat challenges also impair cardiovascular regulation. Whether vitamins have acute beneficial effects on the baroreflex control of HR in smokers is unclear.
Subjects/Methods: A randomized, placebo-controlled crossover study in 30 male smokers (34.2 +/- 6.9 years). Interventions were: (1) moderate (vitamin C (300 mg) and E (75 IU) and folic acid (1 mg)); (2) high doses of vitamins (vitamin C (2 g) and E (800 IU), and folic acid (5 mg)); or, (3) placebo. Vitamins were ingested with cream (a high-fat challenge) or milk (low-fat control). Four hours later, blood was withdrawn and radial pulse wave forms recorded via tonometry. Spontaneous beat-to-beat variations in HR and systolic blood pressure (SBP) were analysed by spectral analysis techniques and sympathovagal control of HR and baroreflex sensitivity (BRS) were assessed.
Results: High doses of vitamins increased plasma vitamin C, E and folic acid levels (P < 0.05) with no change in SBP, HR or BRS (P > 0.05, analysis of variance). Plasma vitamin levels did not correlate with any cardiovascular parameters. Moderate vitamins increased the vagal control of HR (+23%; P < 0.05) and cream led to small increases (P < 0.05) in SBP (+2mm Hg) and HR (+2 beats min(-1)) with no change in BRS.
Conclusions: In male smokers, circulating antioxidants had no effect on BRS and minor effects on the cardiovascular system were seen following acute fat and vitamin ingestion.

• 出版日期2009-2