Model selection in measures of vascular parameters using dynamic contrast-enhanced MRI: experimental and clinical applications

作者：Ewing James R^*; Bagher Ebadian Hassan

来源：NMR in Biomedicine, 2013, 26(8): 1028-1041.

DOI：10.1002/nbm.2996

• DCE-MRI
• model selection
• microvascular permeability
• cerebral glioma
• patlak plot

A review of the selection of models in dynamic contrast-enhanced MRI (DCE-MRI) is conducted, with emphasis on the balance between the bias and variance required to produce stable and accurate estimates of vascular parameters. The vascular parameters considered as a first-order model are the forward volume transfer constant K-trans, the plasma volume fraction v(p) and the interstitial volume fraction v(e). To illustrate the critical issues in model selection, a data-driven selection of models in an animal model of cerebral glioma is followed. Systematic errors and extended models are considered. Studies with nested and non-nested pharmacokinetic models are reviewed; models considering water exchange are considered.

• 出版日期2013-8