A Multipathway Coupled Domino Strategy: Metal-free Oxidative Cyclization for One-Pot Synthesis of 2-Acylbenzothiazoles from Multiform Substrates

作者：Zhu, Yan-ping; Jia, Feng-cheng; Liu, Mei-cai; Wu, An-xin^*

来源：Organic Letters, 2012, 14(17): 4414-4417.

DOI：10.1021/ol301921t

• MULTIPLE PATHWAYS
• TANDEM CATALYSIS
• FACILE SYNTHESIS
• ANALOGS

A multipathway coupled domino strategy has been developed for the efficient synthesis of 2-acylbenzothiazoles from multiform substrates arylethenes, arylacetylenes, 2-hydroxy-aromatic ketones, and carbinols via four distinct pathways. Through a logical coupled oxidation/heterocyclization domino process, a variety of 2-acylbenzothiazoles were synthesized free of metal in one pot.

• 出版日期2012-9-7
• 单位华中师范大学