APOE gene and neuropsychiatric disorders and endophenotypes: A comprehensive review

作者：Forero Diego A; Lopez Leon Sandra; Gonzalez Giraldo Yeimy; Dries Daniel R; Pereira Morales Angela J; Jimenez Karen M; Franco Restrepo Juan E

来源：American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 2018, 177(2): 126-142.

DOI：10.1002/ajmg.b.32516

<jats:sec><jats:label /><jats:p>The Apolipoprotein E (<jats:italic>APOE</jats:italic>) gene is one of the main candidates in neuropsychiatric genetics, with hundreds of studies carried out in order to explore the possible role of polymorphisms in the <jats:italic>APOE</jats:italic> gene in a large number of neurological diseases, psychiatric disorders, and related endophenotypes. In the current article, we provide a comprehensive review of the structural and functional aspects of the <jats:italic>APOE</jats:italic> gene and its relationship with brain disorders. Evidence from genome‐wide association studies and meta‐analyses shows that the <jats:italic>APOE</jats:italic> gene has been significantly associated with several neurodegenerative disorders. Cellular and animal models show growing evidence of the key role of APOE in mechanisms of brain plasticity and behavior. Future analyses of the <jats:italic>APOE</jats:italic> gene might find a possible role in other neurological diseases and psychiatric disorders and related endophenotypes.

• 出版日期2018-3