An improved synthesis of trantinterol

作者:Wen, H.*; Qin, L.; Pan, L.; Li, J.; Cheng, M.
来源:Pharmaceutical Chemistry Journal, 2012, 46(5): 313-315.
DOI:10.1007/s11094-012-0788-y

摘要

An efficient synthesis of 2-(4-amino-3-chloro-5-trifluoromethylphenyl)-2-t-butylamino-ethanol (trantinterol), a selective beta(2)-adrenoceptor agonist, has been achieved from inexpensive and commercially available starting material. The synthesis involves the conversion of aryl iodide to aldehyde catalyzed by PdCl2(dppf) as a key step.

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