摘要
An efficient synthesis of 2-(4-amino-3-chloro-5-trifluoromethylphenyl)-2-t-butylamino-ethanol (trantinterol), a selective beta(2)-adrenoceptor agonist, has been achieved from inexpensive and commercially available starting material. The synthesis involves the conversion of aryl iodide to aldehyde catalyzed by PdCl2(dppf) as a key step.