Apparent Half-Lives of Dioxins, Furans, and Polychlorinated Biphenyls as a Function of Age, Body Fat, Smoking Status, and Breast-Feeding

作者：Milbrath Meghan O'Grady^*; Wenger Yvan; Chang Chiung Wen; Emond Claude; Garabrant David; Gillespie Brenda W; Jolliet Olivier

来源：Environmental Health Perspectives, 2009, 117(3): 417-425.

DOI：10.1289/ehp.11781

• elimination rate
• half-life
• pharmacokinetics
• polychlorinated biphenyls
• polychlorinated dibenzofurans
• polychlorinated dibenzo-p-dioxins

OBJECTIVE: In this study we reviewed the half-life data in the literature for the 29 dioxin, furan, and polychlorinated biphenyl congeners named in the World Health Organization toxic equivalency factor scheme, with the aim of providing a reference value for the half-life of each congener in the human body and a method of half-life estimation that accounts for an individual's personal characteristics.
DATA SOURCES AND EXTRACTION: We compared data from > 30 studies containing congener-specific elimination rates. Half-life data were extracted and compiled into a summary table. We then created a subset of these data based on defined exclusionary criteria.
DATA SYNTHESIS: We defined values for each congener that approximate the half-life in an infant and in an adult. A linear interpolation of these values was used to examine the relationship between half-life and age, percent body fat, and absolute body fat. We developed predictive equations based on these relationships and adjustments for individual characteristics.
CONCLUSIONS: The half-life of dioxins in the body can be predicted using a linear relationship with age adjusted for body fat, smoking, and breast-feeding. Data suggest an alternative method based on a linear relationship between half-life and total body fat, but this approach requires further testing and validation with individual measurements.

• 出版日期2009-3