A Simple Synthesis of N-beta-Fmoc/Z-Amino Alkyl Thiols and their use in the Synthesis of N-beta-Fmoc/Z-Amino Alkyl Sulfonic Acids

作者：Sureshbabu V V^*; Vishwanatha T M; Vasantha B

来源：Synlett, 2010, 2010(7): 1037-1042.

DOI：10.1055/s-0029-1219584

• alkyl iodides
• thiourea
• alkyl thiols
• N-protected taurines
• isothiuronium salts

A simple and efficient protocol for the synthesis of N-beta-Fmoc/Z-amino alkyl thiols is described. The approach uses sodium pyrosulfite-mediated hydrolysis of isothiouronium salts resulting from the reaction between N-protected aminoalkyl iodides and thiourea. N-Protected taurines were prepared through performic acid oxidation of the thiols and the products were further utilized for the synthesis of dipeptidosulfonamides.

• 出版日期2010-4