A weekly 35,000 IU vitamin D supplementation improves bone turnover markers in vitamin D deficient Saudi adolescent females

作者：Sulimani Riad A^*; Mohammed Ashry G; Alshehri Suliman N; Alfadda Assim A; Al Othman Abdulaziz; Khan Aliya A

来源：Archives of Osteoporosis, 2017, 12(1): 85.

DOI：10.1007/s11657-017-0379-3

• Vitamin D deficiency
• Bone turnover markers
• Adolescents

This study examined the effects of weekly 35,000 IU vitamin D supplementation for 4 weeks on bone turnover markers (BTMs). There was improvement in the levels of parathyroid hormone (PTH), osteocalcin, and carboxy-terminal telopeptides of crosslinks of type 1 collagen (beta CTX) which paralleled the increase in vitamin D levels.
Purpose The effects of vitamin D supplementation on bone turnover markers (BTMs) have been inconsistent. This study examined the effects of weekly 35,000 IU vitamin D supplementation for 1 month on BTMs.
Methods Sixty-eight vitamin D deficient adolescent females were given 35,000 IU of vitamin D3 for 4 weeks. Pre and post intervention blood samples were taken for 25(OH) D, PTH, osteocalcin and beta CTX.
Results There was a significant increase in serum 25 (OH) D in the post intervention period which was accompanied by a significant decrease in PTH, osteocalcin and beta CTX (P < 0.001).
Conclusions We concluded that weekly 35,000 IU vitamin D supplementation for 4 weeks results in significant improvement of BTMs.

• 出版日期2017-9-30