General and Green Synthesis of C-6 Sulfonylmethyl 4-Aryl-3,4-dihydropyrimidinones in Water

作者:Quan Zheng Jun; Wei Qiang Bing; Ma Dong Dong; Da Yu Xia; Wang Xi Cun*; Shen Mao Sen
来源:Synthetic Communications, 2009, 39(12): 2230-2239.
DOI:10.1080/00397910802654682

摘要

A simple, inexpensive, and green reaction permitting the synthesis of new C-6 arylsulfonylmethyl 4-aryl-3,4-dihydropyrimidinones in water by S-alkylation of 6-bromomethyl 3,4-dihydropyrimidinones 2 with benzenesulfinic acid anions 3 is reported. The required 6-bromomethyldihydropyrimidone precursors 2 were readily prepared using an organic solid brominating reagent.