An Efficient Synthesis of Fluorinated Azaheterocycles by Aminocyclization of Alkenes

作者：Huang Hai Tsang; Lacy Tyler C; Blachut Barbara; Ortiz Gerardo X Jr; Wang Qiu^*

来源：Organic Letters, 2013, 15(8): 1818-1821.

DOI：10.1021/ol4003866

A general and efficient approach to important fluorinated azaheterocycles has been developed by incorporating nucleophilic fluorination into alkene difunctionalization. This intramolecular aminofluorination transformation of alkenes has been achieved via the aminocyclization of reactive unsaturated N-iodoamines, which can be generated in situ from either unsaturated N-chloramines or their amine precursors in a one-pot protocol.

• 出版日期2013-4-19