Nicotinamide Benzimidazolide Dinucleotides, Non-Cyclisable Analogues of NAD(+)

作者：Redpath Philip; Haluszczak Jolanta; Macdonald Simon J; Migaud Marie E^*

来源：Synlett, 2014, 25(16): 2331-2336.

DOI：10.1055/s-0034-1379000

• nucleotides
• benzimidazoribosyl nucleosides
• phosphorylation
• cyclic adenosine diphosphoribose
• enzymes

Benzimidazole-based nucleotides and dinucleotides have been synthesised to increase the range of chemical tools available to probe the NAD(+) biology space. They were examined for their reactivity in alkylation-type reactions, where they yielded unstable alkylated heteoaromatic adducts, both chemically and enzymatically. While unsuited for NAD(+) cyclases, these NAD(+) analogues could be viable substrates for non-adenine modifying NAD(+)-dependent enzyme classes.

• 出版日期2014-10