Ag-Carbenoid-Initiated Catalytic Hydration Cascades: Rapid Construction of Functionalized Bicyclo[3.3.1]nonanes

作者：Wang, Lu; Cai, Shunyou; Xing, Xiangyou; Gao, Ying; Wang, Tao^*; Wang, David Zhigang

来源：Organic Letters, 2013, 15(10): 2362-2365.

DOI：10.1021/ol4006954

• PROPARGYLIC ESTERS
• CYCLOISOMERIZATION
• CYCLOPROPANATION
• CYCLOADDITION
• REARRANGEMENT
• ACETATES

Remarkable Ag-carbenoid-initiated enone cyclopropanation-hydrolytic fragmentation-competitive 1,2-vs-1,4 addition reaction cascades were uncovered on a range of propargylic esters tethered to cyclohexadienones, leading to the highly efficient and stereospecific construction of densely functionalized bicyclo[3.3.1]nonanes under mild conditions.

• 出版日期2013-5-17
• 单位北京大学