Antibodies to phosphatidylserine/prothrombin complex as an additional diagnostic marker of APS?

作者：Zigon P^*; Cucnik S; Ambrozic A; Semrl S Sodin; Kveder T; Bozic B

来源：Lupus, 2012, 21(7): 790-792.

DOI：10.1177/0961203312444173

• antiprothrombin antibodies
• phosphatidylserine-dependent antiprothrombin antibodies
• avidity
• enzyme immunoassays
• antiphospholipid syndrome

Antiprothrombin antibodies can be measured by ELISA using either a prothrombin/phosphatidylserine complex (aPS/PT) or prothrombin alone (aPT) as antigen. We aimed to compare the clinical features of autoimmune patients with avidity of aPS/PT and determine the diagnostic efficiency of aPS/PT and aPT for assessing antiphospholipid syndrome (APS). aPS/PT were of low (n = 9), heterogeneous (n = 31) and high (n = 8) avidity out of 48 cases. None of the samples with low avidity were positive in aPT ELISA. Among patients with heterogeneous or high avidity aPS/PT, there was a significantly greater number of patients with APS as compared to patients with low avidity (38/39 vs. 7/9; p %26lt; 0.05). No SLE patients had high avidity antiprothrombin antibodies. Lupus (2012) 21, 790-792.

• 出版日期2012-6