A model for improving the treatment and care of Alzheimer's disease patients through interdisciplinary research

作者：Trojanowski John Q^*; Arnold Steven E; Karlawish Jason H; Naylor Mary; Brunden Kurt R; Lee Virginia M Y

来源：Alzheimer's and Dementia, 2012, 8(6): 564-573.

DOI：10.1016/j.jalz.2011.08.005

• Drug discovery
• Biomarkers
• Clinical trial design
• Continuity of care
• Alzheimer's disease

The emerging global epidemic of Alzheimer's disease (AD) demands novel paradigms to address the two unmet needs of the field: (a) cost-effective health care delivery programs/services, and (b) clinical and basic research to accelerate therapy discovery/development. This report outlines a model demonstration project, the Marian S. Ware Alzheimer Program at the University of Pennsylvania, which was designed to achieve four specific aims: (1) improve the integration and continuity of AD care; (2) identify biomarkers that detect the earliest presence of AD and related neurodegenerative cognitive disorders; (3) enhance both the design and conduct of clinical trials as well as review their results to more effectively test new AD therapies and translate valuable therapies into clinical practice; and (4) discover and develop novel disease-modifying small molecule treatments for AD.
The "Ware-UPenn" program has been presented in this report as a useful prototype for partnerships between private philanthropy and academia in planning and developing programs to address a major national public health problem.

• 出版日期2012-11