Abobotulinum toxin A and onabotulinum toxin A for masseteric hypertrophy: a split-face study in 25 Korean patients

作者：Lee Soo Hyun; Wee Seong Ho; Kim Hyung Joo; Yeo Un Cheol; Lee Nam Ho; Lee Se Won; Cho Sung Bin^*

来源：Journal of Dermatological Treatment, 2013, 24(2): 133-136.

DOI：10.3109/09546634.2011.617354

• masseteric hypertrophy
• onabotulinum toxin A
• abobotulinum toxin A
• conversion ratio

Masseter muscle hypertrophy has been treated for cosmetic purposes using several modalities, including injection of type A or type B botulinum toxin into the masseter muscle. In this report, we compared the efficacy and safety of abobotulinum toxin A with onabotulinum toxin A treatment for masseteric hypertrophy in 25 Korean patients with a conversion factor of 2.5:1 through a controlled, split-face, and evaluator-blinded study. The mean grade of clinical improvement based on clinical assessment was 2.8 +/- 0.9 for abobotulinum toxin A and 2.7 +/- 0.8 for onabotulinum toxin A at 8 weeks after the injection. At 12 weeks after the injection, the mean grade of clinical improvement based on clinical assessment was 2.9 +/- 0.9 for abobotulinum toxin A and 2.7 +/- 0.8 for onabotulinum toxin A. More pronounced improvement was observed with abobotulinum toxin A than onabotulinum toxin A in three (12%) patients at 8 weeks and five (20%) patients at 12 weeks. We believe that our data can be used as an essential reference for determining the dose of type A botulinum toxin in the treatment of masseteric hypertrophy.

• 出版日期2013-4