Absence of Change in Corrected QT Interval in Children and Adolescents Receiving Antipsychotic Treatment: A 12 Month Study

作者：Alda Jose A^*; Munoz Samons Daniel; Tor Jordina; Merchan Naranjo Jessica; Tapia Casellas Cecilia; Baeza Inmaculada; Calvo Escalona Rosa; Castro Fornieles Josefina; Martinez Cantarero Carmen; Andres Nestares Patricia; Fernandez Aviles Francisco; Arango Celso

来源：Journal of Child and Adolescent Psychopharmacology, 2016, 26(5): 449-457.

DOI：10.1089/cap.2015.0151

Background: Prescriptions of antipsychotic drugs (AP) in children and adolescents have significantly increased in Europe as well as in the United States. However, there is limited evidence of the cardiac safety of second-generation antipsychotics (SGA) in the pediatric population.
Objective: The aim of the study is to evaluate the cardiac side effects of SGA in children and adolescents, and how they are influenced by clinical, demographic, and treatment factors.
Methods: This article presents a naturalistic, longitudinal, multicenter study conducted in 216 treatment-naive or quasi-naive children and adolescents receiving AP treatment. It analyzed the possible influence of AP treatment on variables such as corrected QT (QTc) intervals and heart rate for a period of 12 months (baseline, 3 months, 6 months, and 12 months). Differences among the three main prescribed drugs used in the sample (risperidone, quetiapine, and olanzapine) were assessed.
Results: A total of 211 received one of the three most prescribed AP (quetiapine, risperidone or olanzapine). There were no significant QTc variations in the sample during follow-up (p = 0.54). There were no differences in QTc rates between the different SGA (risperidone-olanzapine p = 0.43; risperidone-quetiapine p = 0.42; olanzapine-quetiapine p = 0.23). When demographic, clinical, or concomitant treatment variables were considered, only baseline overweight correlated with QTc prolongation (p = 0.003). The heart rate in the whole sample tended to decrease during follow-up (p = 0.054). However, patients on quetiapine showed increased heart rate compared with those on risperidone (p = 0.04).
Conclusions: In this sample, SGA seem to have a safe heart side effect profile in the child and adolescent population. There was no observed mean increase in QTc or in heart rate.

• 出版日期2016-6