An Expeditious Method for the Preparation of 2-Hydroxy-1,4-dioxane and Its Use in Reductive Alkylation of Amines

作者：Vinter Adrijana^*; Avdagic Amir; Stimac Vlado; Palej Ivana; Cikos Ana; Sunjic Vitomir; Alihodzic Sulejman

来源：Synthesis, 2010, 2010(2): 255-258.

DOI：10.1055/s-0029-1217101

• diethylene glycol
• oxidations
• reductive alkylations
• 2-hydroxy-1,4-dioxane
• ruthenium(VIII) catalysis

Selective oxidation of diethylene glycol by a ruthenium(VIII) species, obtained in situ from ruthenium(III) chloride-sodium periodate in the presence of a catalytic quantity of water, affords a monoaldehyde in the form of the internal acetal 2-hydroxy1,4-dioxane. This compound was used in reductive alkylations of selected primary and secondary amines, demonstrating its utility in the preparation of target structures with the 2-(2-hydroxyethoxy) ethylamino unit.

• 出版日期2010-1